Health-related quality of life after isolated limb perfusion compared to extended resection, or amputation for locally advanced extremity sarcoma: Is a limb salvage strategy worth the effort?

e23539 Background: Induction isolated limb perfusion (ILP) followed by limb-sparing resection or extended are frequently used salvation strategies (LSS) in locally advanced extremity soft tissue sarcoma (eSTS) to prevent amputation. However little is known about the long term health-related quality of life (HRQoL) these patients. The aim this study was compare long-term patient reported outcomes (PROs) such as HRQoL after ILP compared Methods: Patients treated with an ILP, resection, amputation were selected from respondents a multi-institutional cross-sectional cohort survivorship (SURVSARC) conducted 2-10 years diagnosis among survivors registered Netherlands Cancer Registry (NCR). Extended defined for stage III eSTS, details regarding levels other than upper lower unknown. Used PROs EORTC QLQ-C30, worry scale (CWS), Hospital Anxiety and Depression Scale (HADS), Toronto Extremity Salvage Score (TESS). Results: We identified 96 eSTS assigned them into four groups: (N = 20), 48), primary 8). While there no differences between resections, results showed better functioning functionality two LSS groups versus groups. scored significantly on QLQ-C30 physical (p < 0.001, 62.7 65.7 78.0 84.1) role 0.038, 67.5 52.8 79.2 80.9), which both account difference ‘medium’ clinical relevance. Also TESS, scores (upper p 0.007 68.9 71.6 93.3 91.1; 0.001 72.2 50.9 84.5 85.5). There significant cancer worry, anxiety depression found all Conclusions: Based study, not inferior however it superior maintenance amputation.[Table: see text]